CLINICAL STUDIES

ACTIVE CLINICAL STUDIES

CPNS Pilot Study

The CPNS Pilot Study is an investigational study evaluating the safety and performance of the CPNS System in patients hospitalized for Acute Decompensated Heart Failure (ADHF). This study is currently enrolling patients in the United States, the European Union, and Panama. To learn more about this study and participating research centers, click here.

002_Infographic-cal-clr.jpg
002_Infographic-heart-clr.jpg

The STIM-ADHF Study

The STIM-ADHF Study is an investigational study evaluating the safety and performance of the CPNS System in patients hospitalized for ADHF. This study is currently enrolling patients in the European Union and Panama. To learn more about this study and participating research centers, click here.

FOUNDATIONAL CLINICAL EVIDENCE

The CPNS 2 Feasibility Study

This investigational feasibility study evaluated the short-term safety and feasibility of the CPNS System over a period of 1-3 hours in patients with chronic heart failure. The study demonstrated that the CPNS System can reproducibly increase contractility with a neutral effect on heart rate.

dk-bkgd-gradient.jpg
002_Infographics-1.png

Single Center Proof of Concept Experience

This proof-of-concept, investigational study demonstrated that stimulation of the cardiac autonomic nerves in 10 patients with stable heart failure, increased contractility without a significant change in heart rate, click here.

1. Mickelsen SR, Marin y Kall C, Cuchiara M, Ebner A. Catheter-based Cardiopulmonary Nerve Stimulation Impacts Left Ventricular Contractility and Relaxation: First In Human Experience. HFSA 2021