CLINICAL STUDIES
ACTIVE CLINICAL STUDIES
STOP-ADHF Study
The STOP-ADHF Study is an investigational study evaluating the safety and performance of the CPNS System in patients hospitalized for Acute Decompensated Heart Failure (ADHF). This study is currently enrolling patients in the United States, the European Union, and Panama. To learn more about this study and participating research centers, click here.
STIM-ADHF Study
The STIM-ADHF Study is an investigational study evaluating the safety and performance of the CPNS System in patients hospitalized for ADHF. This study is currently enrolling patients in the European Union. To learn more about this study and participating research centers, click here.
FOUNDATIONAL CLINICAL EVIDENCE
The CPNS 2 Feasibility Study
This investigational feasibility study evaluated the short-term safety and feasibility of the CPNS System over a period of 1-3 hours in patients with chronic heart failure. The study demonstrated that the CPNS System can reproducibly increase contractility with a neutral effect on heart rate.
Single Center Proof of Concept Experience
This proof-of-concept, investigational study demonstrated that stimulation of the cardiac autonomic nerves in 10 patients with stable heart failure, increased contractility without a significant change in heart rate, click here.
1. Mickelsen SR, Marin y Kall C, Cuchiara M, Ebner A. Catheter-based Cardiopulmonary Nerve Stimulation Impacts Left Ventricular Contractility and Relaxation: First In Human Experience. HFSA 2021